This shape-shifting tale of the perils and pleasures of self-reinvention begins at a dinner party, when Tom's (Michael Shannon) co-worker arrives with an intriguing date named Alice (Rachel Weisz). Tom is convinced he knows her, but she refuses to acknowledge their history. And when Alice makes a hasty exit, Tom sets off after her. What follows is an all-night odyssey shared by two people, one needing to change his life, the other questioning how to stop changing.

This film's center is a family in Albania. The main characters are Rudina, the oldest daughter, and Nik, the oldest son. Both have a pretty normal life. Rudina is an A-student in high-school and Nik very popular. He just fell in love with one of his fellow students. Their father earns the families income with a little bread delivery service. For that he uses a short cut through the neighbours ground, but the neighbour doesn't necessarily like that. But the ground had actually belonged to Rudina's and Nik's family once. One day the conflict escalates and the neighbour gets killed by Rudina's and Nik's father and their uncle. Because only their uncle gets caught by the police and their father is able to hide, the old law of blood feud is against the family. They cannot leave their house. Only the women of the family are allowed to leave the house. So Rudina has to quit school and continue the bread delivery service of the father, so the family can survive. The situation is tense as ...

In a small village in Colombia, the pregnant seventeen years old Maria supports her family with her salary working in a floriculture. She is fired and with a total lack of perspective of finding a new job, she decides to accept the offer to work as a drug mule, flying to USA with sixty-two pellets of cocaine in her stomach. Once in New York, things do not happen as planned.